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TITLE CIRM Institute ABSTRACT This application will describe the depth and breadth of our Stem Cell Programs in the CIRM Institute category. We are requesting funds to help with the construction costs for our Institute of Stem Cell Biology and Regenerative Medicine, a free-standing new building dedicated to our Stem Cell Programs. Currently, our stem cell program and our faculty are spread across laboratories both on and off campus. Our Institute represents a unique university-wide collaboration that brings life, physical, and engineering sciences together with leaders in business, law, and education. Our stem cell programs include all three elements in the RFA: basic and discovery research (Element X), pre-clinical research (Element Y), and pre-clinical and clinical research (Element Z). The new building will house faculty who were present prior to launching our Institute of Stem Cell Biology and Regenerative Medicine, new faculty that have been recruited since 2002, and faculty who we anticipate recruiting in the next five to ten years. Our stem cell programs in Element X focus on areas including embryonic stem cell biology, reprogramming of adult somatic cells, tissue and organ adult stem and progenitor cells, and cancer stem cells. Our Stem Cell Programs in Element Y focus on ten area/organ systems for pre-clinical research. The stem cell efforts in pre-clinical development and pre-clinical research, Element Z, are currently robust in hematopoietic cell transplantation and cancer stem cells. We anticipate that as our programs in human embryonic stem cell research and reprogramming develop over the next decade, there will be a parallel progression from Elements X and Y into Element Z. The new building will house relevant faculty supported by state-of-the-art core facilities including an animal vivarium with in molecular imaging, human embryonic teaching laboratory, and cell and tissue bank. In addition to the scientific cores, the new structure will house space for our Program in Regenerative Medicine and clinical trial support. Finally, we have a strategic plan to recruit new faculty in all areas of our stem cell program over the next five to seven years. Clearly, not all of our stem cell faculty and programs will be housed in the new facility, but it will act as the
PI N/A INSTITUTE Stanford University STATE California AMOUNT $43,578,000.00 AWARD DATE 2008 May GRANT TYPE Major Facilities